Custom Peptides
Cayman Chemical HArgGlyAspCysOHtrIfluo 10mg
An RGD-containing tetrapeptide; inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets (IC50s = 320 and 35 µM, respectively); implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs; has been conjugated to polyethylenimine to improve gene transfection efficiency
Cayman Chemical 5 6-epoxy Cholestnol 10mg
An oxidative metabolite of cholesterol; formed via radical and non-radical oxidation of cholesterol at the 5,6-double bond; induces release of LDH and apoptosis in macrophage-differentiated U937 cells; has been found in human fatty streaks and advanced atherosclerotic lesions
Cayman Chemical 1 2DIpalmItoylsnglycero3 10mg
A biotinylated phospholipid; has been used in various SLB systems to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics, detect protein-ligand binding, or create DNA curtains in nanowells for high-throughput detection of protein-DNA interactions at the single molecule level
Cayman Chemical Loxoprofen-SRS 10mg
An NSAID, a COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively), and an active metabolite of loxoprofen; intravenous administration inhibits acetic acid-induced writhing, reduces carrageenan-induced mechanical hyperalgesia, and decreases carrageenan-induced paw edema in rats (ED50s = 0.43, 1.28, and 8.01 mg/kg, respectively)
Cayman Chemical CaMKII-IN-1 10mg
A CaMKII inhibitor (IC50 = 0.063 µM); is selective for CaMKII over CaMKIV, MLCK, p38α, Akt1, and PKC (IC500s = >60, 36, 11, 30, and 21 µM, respectively)
Cayman Chemical 2DeoxyadenosIn5OdIphos 10mg
A nucleotide diphosphate; inhibits the polymerization of ADP and CDP by E. coli or P. fluorescens polynucleotide phosphorylase at 0.23 mM; levels are increased in erythrocytes isolated from patients with adenosine deaminase deficiency and SCID
Cayman Chemical 2OAcetyl20hydroxyecdyson 10mg
An ecdysone steroid hormone; completely inhibits the growth of the bacteria S. aureus, E. coli, and P. vulgaris, as well as the fungi C. albicans, A. alternata, and F. solani at 10 UG/ml; increases aggregation of Aβ42, increases fibril formation by 60%, and decreases oligomer levels in cell-free assays at 50 µM; reduces Aβ42-induced cytotoxicity of SH-SY5Y cells at 5 and 10 µM
Cayman Chemical Gelsemum elegns Koumn 10mg
An alkaloid with diverse biological activities; inhibits the proliferation of MCF-7 cells (IC50 = 124 UG/ml) as well as induces apoptosis and cell cycle arrest at the G2/M phase in the same cells; reduces LPS-induced increases in iNOS, IL-1β, IL-6, and TNF-α levels in RAW 264.7 macrophages at 200 and 400 UG/ml; inhibits acetic acid-induced writhing and formalin-induced paw licking and biting in mice at 2 and 10 mg/kg; increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, at 0.4-10 mg/kg
Cayman Chemical 2-OL-GalactopyrnosylorI 10mg
A flavonoid glycoside with anti-inflammatory activity; decreases LPS-induced production of NO, IL-6, and TNF-α in RAW 264.7 cells from 100-200 µM
Cayman Chemical Amentoflavon 10mg
A biflavonoid; has antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities; has antiviral activity against the influenza A subtypes H1N1 and H3N2, influenza B, and herpes simplex virus 1 (EC50s = 3.1 and 4.3, 0.56, and 17.9 UG/ml, respectively); inhibits hydrolysis of p-NPP catalyzed by PTP1B (IC50 = 7.3 µM); reduces depressive-like behavior in mice
Cayman Chemical Cardnol dIen 10mg
A tyrosinase inhibitor (IC50 = 52.5 μM); used to synthesize cardanol-metal complexes
Cayman Chemical 5trns Fluprostnl Isopropy 10mg
A potential impurity in commercial preparations of travoprost
Cayman Chemical 17phenyl TRNor PROSGlndI 10mg
A form of 17-phenyl trinor PGF modified with a cyclohexane moiety at the alpha carbon; insoluble in aqueous media, soluble in organic solvents; activity at the FP receptor has not been evaluated